Category Archives: diabetes

RB2015 Rejuvenation Biotechnology Conference Aug 19-21

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Undergraduate at The University of Southern Indiana + More Years Less Tears + Your NeXt Computer
After 15+ years as an IT professional. Jonathon decided to return to school in hopes of one day troubleshooting the most universal problem effecting all. Death, pain, and suffering by aging. As an undergraduate he is currently performing research in Dr. Richard Bennetts lab at the University of Southern Indiana, as well as volunteering for various organizations including the Buck Institute for research on Aging.
Jonathon Fulkerson
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RB2015

WHO ATTENDS

  • Academic Researchers
  • Pharmaceutical and Biotech Industry
  • Undergrad, Graduate and Post Doctorial Students
  • Nonprofits
  • Regulatory
  • Investors
  • The General Public

WHY ATTEND

  • Focused tracks covering three key elements of successful drug development: clinical review, therapeutic approaches, industry and policy
  • In depth examination of advances in tissue engineering and gene therapy
  • More interactivity – 6 hours of interactive discussion sessions and 17 hours of networking
  • Jobs Board – review and share the expertise needs of the industry’s leading research and development organizers
  • Understand and shape the scientific and investment opportunities of the new Rejuvenation Biotechnology Industry
  • Extended poster sessions
  • Back by popular demand – our opening evening’s entertainment will be Hal Sparks – Comedian, Actor and Musician.

Cheap Blood Pressure Drug Cures Diabetes In Mice, Human Trials Announced

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Undergraduate at The University of Southern Indiana + More Years Less Tears + Your NeXt Computer
After 15+ years as an IT professional. Jonathon decided to return to school in hopes of one day troubleshooting the most universal problem effecting all. Death, pain, and suffering by aging. As an undergraduate he is currently performing research in Dr. Richard Bennetts lab at the University of Southern Indiana, as well as volunteering for various organizations including the Buck Institute for research on Aging.
Jonathon Fulkerson
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November 9, 2014 | by Stephen Luntz (original source here)

mix_Diabetes-Shalev-graphic2

Funding has been secured for a clinical trial of a drug that not only prevents mice from getting type I diabetes, but actually reverses the condition if it has already taken hold.

Verapamil is a calcium channel blocker used to treat hypertension, irregular heartbeats and some sorts of headaches. It has been approved for some of these purposes for over 30 years.

Verapamil has dangerous interactions with some other drugs. However, while side-effects such as nausea and swollen feet may be unpleasant, the dangers are seldom life threatening, and generally a better alternative to having diabetes. Such a history of long-term usage should shorten the clinical trial process and improve the chances of gaining regulatory approval.

The potential application to diabetes arises from the discovery by Dr. Anath Shalev of the University of Alabama, Birmingham (UAB) that verapamil lowers the level of the protein TXNIP in pancreatic beta cells.

Back in 2002, Shalev, then at the University of Wisconsin-Madison, began a search to find the gene that responded most strongly in the pancreas to excessive glucose levels. This turned out to be the TXNIP gene. Moreover, TXNIP’s full name is thioredoxin-interacting protein; high levels of thioredoxin have been shown to keep the pancreas’ insulin-producing islet beta cells alive.

Shalev began to suspect TXNIP suppression might be the key to fighting diabetes, and subsequent tests in ratsmice and islets isolated from humans have lent weight to her theory.

“We have previously shown that verapamil can prevent diabetes and even reverse the disease in mouse models and reduce TXNIP in human islet beta cells, suggesting that it may have beneficial effects in humans as well,” Shalev said, announcing plans for the clinical trials.

Most recently, Shalev revealed that TXNIP can stimulate its own expression. “These findings support the notion,” Shaleve wrote, “that TXNIP levels rise over time, not only as a result of elevated blood glucose levels and/or endoplasmic reticulum stress, but also as part of a vicious cycle by which increased TXNIP levels lead to more TXNIP expression and thereby amplify the associated detrimental effects on beta-cell biology including oxidative stress, inflammation, and ultimately beta-cell death and disease progression.”

The JDRF funded trial will involve 52 newly diagnosed patients with diabetes, half of whom will be put on verapamil and half on a placebo. All patients will continue to receive insulin pump therapy. “That is a proof-of-concept that, by lowering TXNIP, even in the context of the worst diabetes, we have beneficial effects,” says Shalev. “And all of this addresses the main underlying cause of the disease — beta cell loss. Our current approach attempts to target this loss by promoting the patient’s own beta cell mass and insulin production. There is currently no treatment available that targets diabetes in this way.”

Meanwhile Shalev is starting work on producing molecules with more targeted and efficient versions of verapamil’s effect on TXNIP.