Category Archives: Dr. Aubrey de Grey

New SENS Laboratory at Cambridge via Philanthropist Jason Hope

Jonathon Fulkerson
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Jonathon Fulkerson

Undergraduate at The University of Southern Indiana + More Years Less Tears + Your NeXt Computer
After 15+ years as an IT professional. Jonathon decided to return to school in hopes of one day troubleshooting the most universal problem effecting all. Death, pain, and suffering by aging. As an undergraduate he is currently performing research in Dr. Richard Bennetts lab at the University of Southern Indiana, as well as volunteering for various organizations including the Buck Institute for research on Aging.
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Original – Fight Aging – Article Here and Original – SENS Research Foundation – Article Here

Jason Hope, you might recall, has provided half a million dollars in research funding to the SENS Research Foundation, used to establish a SENS laboratory at Cambridge in order to push forward with the Foundation’s AGE-breaker program. AGE-breakers are drugs or other treatments capable of breaking down advanced glycation end-products (AGEs). These are a class of metabolic waste product that accumulate in our tissues to cause significant harm that includes the progressive loss of elasticity in skin and blood vessels.

There is, on the whole, far too little work undertaken today on AGE-breaker treatments in comparison to the benefits that a treatment could bring. What little research has taken place over the past twenty years unfortunately produced no effective therapies. As it turned out the AGEs that are important in short-lived laboratory animals are not the same at all as those that are important in humans – something that would have been challenging to identify until comparatively recently, and which resulted in promising animal studies that then went nowhere in commercial trials.

Now, however, researchers know that the vast majority of all AGEs in human tissues consist of just one type, called glucosepane – so the way is open for bold philanthropists and forward-looking researchers to build therapies that will be effective in removing this contribution to degenerative aging. Glucospane removal is one of the areas in which the SENS Research Foundation and its backers pick up the slack, undertaking important rejuvenation research that is neglected by the mainstream, even though it was exactly the mainstream research community that produced all of the studies and evidence that demonstrate the important role of glucospane in aging.

In any case, I should point out that Jason Hope runs a website and blog in which he discusses his take on philanthropy and his support for research aimed at extending healthy human life and rejuvenating the old. This makes for an interesting follow-on from yesterday’s post on big philanthropy. More folk of this ilk would certainly be a good thing, and I’m always pleased to see more of the better connected people in this world of ours speaking openly of their support for rejuvenation biotechnology.

Philanthropy

Quote:

Philanthropy has become a big focus for me. The organizations I have chosen to stand behind have come from many facets of my life. One of my passions has become the research done at the SENS Research Foundation. Their involvement in anti aging is not just about wanting to live forever. It’s about creating a longer, better quality of life.Foundations like SENS are taking a different approach to anti-aging. They are focused on finding cures for disease that break down the body and thus cause us to age faster than we should. Disease like Alzheimer’s and heart and lung disease affect all functions of the body. Traditional medicine looks at treating these diseases after they happen. We want to focus on stopping these diseases from ever happening. We have spent so much time focused on medication for treating disease and not enough time on preventing that disease from ever happening.

By supporting scientific research that thrives through innovation and is not afraid to challenge the modern school of thought we will continue to break down walls.

A 21st Century Philanthropic Model For Philanthropy

Quote:

Can you conceive of a world without age-related disease, disability and suffering? What about a world in which it’s possible for the average person to live 120 healthy years? While it may sound like a utopian dream, such a world is the exact goal of some of society’s most brilliant scientists and visionary leaders. At this very minute, groundbreaking work is underway at universities across the globe as researchers attempt to apply regenerative medicine to age-related disease through the repair of damage to tissue, cells and molecules within the body. While this research couldn’t be possible without the leadership of the world’s wealthiest philanthropists, it also relies upon the collective power of everyday people who have joined forces in their commitment to a better quality of life for all.Traditionally, big ticket donors have been the primary target for fundraising programs. Research has consistently shown that the bulk of donor funds come from a small percentage of the wealthiest donors: in fact, a full 75 percent of funds raised come from gifts of over $1 million.

Instead of resigning themselves solely to the influence of the individual, non-profits are turning to the collective power of a group. The MFoundation’s “The 300 Pledge” fundraising campaign is an exciting example of this method in practice. The 300 Pledge asks 300 funders to commit $1,000 a year for 25 years toward critical research aimed at ending age-related diseases. When broken down, this goal is manageable for many households: just $3 a day or $85 a month – less than your daily tab at Starbucks. Obviously, the model is working: to date, 291 people have taken up the challenge, with nine spots remaining.

As evidenced by the magnificent philanthropy of people like Peter Thiel, Bill Gates and others like them, it’s obvious that one person can make a difference. However, fundraising challenges, like MFoundation’s “The 300,” also demonstrate the power of a dedicated group of people to foster real world change for the billions of people living in the world today as well as the generations that follow. In doing so, those who take up the challenge create a unique and world-altering legacy for themselves.

Joe Rogan Experience #638 – Aubrey de Grey

Jonathon Fulkerson
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Jonathon Fulkerson

Undergraduate at The University of Southern Indiana + More Years Less Tears + Your NeXt Computer
After 15+ years as an IT professional. Jonathon decided to return to school in hopes of one day troubleshooting the most universal problem effecting all. Death, pain, and suffering by aging. As an undergraduate he is currently performing research in Dr. Richard Bennetts lab at the University of Southern Indiana, as well as volunteering for various organizations including the Buck Institute for research on Aging.
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Joe Rogan Aubrey de Grey

Published on Apr 22, 2015

Aubrey de Grey is an English author and theoretician in the field of gerontology and the Chief Science Officer of the SENS Research Foundation. http://sens.org/

RB2015 Rejuvenation Biotechnology Conference Aug 19-21

Jonathon Fulkerson
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Jonathon Fulkerson

Undergraduate at The University of Southern Indiana + More Years Less Tears + Your NeXt Computer
After 15+ years as an IT professional. Jonathon decided to return to school in hopes of one day troubleshooting the most universal problem effecting all. Death, pain, and suffering by aging. As an undergraduate he is currently performing research in Dr. Richard Bennetts lab at the University of Southern Indiana, as well as volunteering for various organizations including the Buck Institute for research on Aging.
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RB2015

WHO ATTENDS

  • Academic Researchers
  • Pharmaceutical and Biotech Industry
  • Undergrad, Graduate and Post Doctorial Students
  • Nonprofits
  • Regulatory
  • Investors
  • The General Public

WHY ATTEND

  • Focused tracks covering three key elements of successful drug development: clinical review, therapeutic approaches, industry and policy
  • In depth examination of advances in tissue engineering and gene therapy
  • More interactivity – 6 hours of interactive discussion sessions and 17 hours of networking
  • Jobs Board – review and share the expertise needs of the industry’s leading research and development organizers
  • Understand and shape the scientific and investment opportunities of the new Rejuvenation Biotechnology Industry
  • Extended poster sessions
  • Back by popular demand – our opening evening’s entertainment will be Hal Sparks – Comedian, Actor and Musician.

Why Aubrey de Grey Takes an Interdisciplinary Approach to Aging

Jonathon Fulkerson
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Jonathon Fulkerson

Undergraduate at The University of Southern Indiana + More Years Less Tears + Your NeXt Computer
After 15+ years as an IT professional. Jonathon decided to return to school in hopes of one day troubleshooting the most universal problem effecting all. Death, pain, and suffering by aging. As an undergraduate he is currently performing research in Dr. Richard Bennetts lab at the University of Southern Indiana, as well as volunteering for various organizations including the Buck Institute for research on Aging.
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aubrey

Why Aubrey de Grey Takes an Interdisciplinary Approach to Aging from Singularity University on Vimeo.

HARDtalk Aubrey De Grey chief science officer and co founder of the SENS Foundation

Jonathon Fulkerson
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Jonathon Fulkerson

Undergraduate at The University of Southern Indiana + More Years Less Tears + Your NeXt Computer
After 15+ years as an IT professional. Jonathon decided to return to school in hopes of one day troubleshooting the most universal problem effecting all. Death, pain, and suffering by aging. As an undergraduate he is currently performing research in Dr. Richard Bennetts lab at the University of Southern Indiana, as well as volunteering for various organizations including the Buck Institute for research on Aging.
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aubrey

 

http://en.wikipedia.org/wiki/Aubrey_D…
Imagine life without aging. You could live for hundreds of years with the mental and physical attributes of your 25 year old self. Would you be tempted? HARDtalk speaks to a scientist and futurologist who believes it is a proposition that 21st century biotechnology will soon be able to deliver. Aubrey de Grey’s Californian research foundation is spending millions of dollars in a bid to conquer the aging process. Is his vision inspiring, daft, or downright dangerous?

How to fight the aging process and prolong life.

Jonathon Fulkerson
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Jonathon Fulkerson

Undergraduate at The University of Southern Indiana + More Years Less Tears + Your NeXt Computer
After 15+ years as an IT professional. Jonathon decided to return to school in hopes of one day troubleshooting the most universal problem effecting all. Death, pain, and suffering by aging. As an undergraduate he is currently performing research in Dr. Richard Bennetts lab at the University of Southern Indiana, as well as volunteering for various organizations including the Buck Institute for research on Aging.
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MYLT POSTS PICTURES TEMPLATE

Original Article Here

“We should not regard aging as a fact of life”

British gerontologist Aubrey de Grey firmly believes that humans can live to be 1000 years old. He spoke with Sara Steinert about his mission to fight the aging process and the similarities between the human body and an airplane.

The European: Dr. de Grey, for many years, people thought of human aging as inevitable, as part of our biology. Is that still true?

de Grey: I would not say that it is wrong. Aging is certainly a side effect of being alive. It is the accumulation of damage that the body does to itself as a by-product of its normal operations. In that sense it is exactly the same as the aging process of a car or an airplane. So really it is not even biology, it is just physics. The big mistake that people make is not in their understanding of what aging is, but in the misunderstanding of what the diseases of old age are: things like Alzheimer’s, cancer, or cardiovascular disease.

The European: How are they mistaken?
de Grey: Most people think of those diseases as like infections – things that could be eliminated from the body using sophisticated medicine. An enormous amount of money and effort is being spent on that, although it is impossible to cure them because these things are part of aging and of being alive in the first place. The only way we can ever tackle those diseases is by tackling the whole package. By preventative maintenance against the damage of being alive.

The European: With stem cell therapies, for example?
de Grey: That is one part of it. But aging is not one single process but an accumulation of a lot of different types of damage in different organs and body parts as a result of different processes. In order to comprehensively tackle all of these types of damage, we have to do a lot of different things at the same time.

The European: Do you believe that your therapies will be able to regenerate all body parts, even brain cells?
de Grey: The single most challenging part of fighting aging is cancer. It is especially difficult because it has natural selection on its side. A cancerous tumor that is big enough to be clinically important has a trillion cells. Each of those cells is independently trying to do creative things to grow faster and escape from anything that the doctor is throwing at it. The most sophisticated and elaborate part of our work involves trying to tackle that. The difference between the brain and the rest of the body is an important difference, but it’s not as big a difference as you might think. It is true that brain cells don’t naturally regenerate very much, but there is plenty of very high-quality and advanced stem cell research going on for the brain and the rest of the body.

The European: You claimed that there is at least one person alive today that will live to be a thousand years old.
de Grey: I never said that this is certain. But yes, I think it’s very likely that the first person to live up to a thousand is already alive.

The European: What kind of person would this be?
de Grey: People who break the world record for longevity are always people who are naturally built to live a long time. Today, people occasionally live up to 110 years. It’s probably going to be someone like that. Someone who may be 50 or 60 or 70 years old today but is doing unusually well for her or his age. The applicability of any therapy will always depend on how healthy a person is. The people who will be the oldest beneficiaries will simply be the people who are aging more slowly before the therapies come along.

The European: So you don’t think it’s a certain kind of personality that is interested in extending life?
de Grey: That is a completely different and mistaken way of looking at it, because we do not make decisions about what we want on the basis of how long ago we were born. We make decisions on the basis of how we perceive the future. I don’t often meet people who want to get sick. So if you have the opportunity not to get sick you won’t get sick and probably won’t die soon.

“A 50/50 chance is enough to be worth fighting for”

The European: How would the “seasons of life” change for us if our time on earth were extended to 1000 years?
de Grey: I don’t find it very productive to think about that, because we are talking about the distant future. So many other things are going to be different in the distant future as a result of other technological breakthroughs. All I really care about is that I don’t want to get sick when I am older. I know that this is unambiguously going to be a good thing.

The European: But what decisions would we have to make? Could I choose for example to always be 20, 40, or 60 years old?
de Grey: Yes, exactly. The best way to think about it is to remember that we are talking about preventative maintenance. So, again, you can think about it in exactly the same way as you think about preventative maintenance on a car or an airplane. The state of physical and mental health will be determined by how thoroughly and how frequently we do the maintenance. So more frequent and thorough maintenance will allow you to be biologically twenty or twenty-five, while less frequent and thorough maintenance will make you a constantly middle-aged person.

The European: From what age on could these therapies be used?
de Grey: Twenty would probably be the minimum biological age that you can maintain. Because if we apply this preventative maintenance it actually rejuvenates people. It takes people back to a younger biological age than they were before the treatment. That means that you don’t have to make a decision when you are 20. You can be 50 already and you could go back to being biologically 25. That is the sensible thing to think about, because as time goes on, these therapies will be getting better. They will be getting more comprehensive, more convenient, and safer.

The European: Who would be able to afford these therapies?
de Grey: That’s a good question. These therapies will not be expensive. They will be made available to everybody who needs them. Because unlike today’s high-tech medicine which is very expensive, these therapies will pay for themselves. They will save us all of the money we are currently spending trying to keep people alive with medicine that doesn’t work. This will also have an enormous number of very effective indirect economic benefits. One is that the children of the elderly will be more productive because they won’t have to spend any time looking after their sick parents. The older but healthy people themselves will be continuing to contribute wealth to society instead of just consuming wealth. Any way you look at it, it would be economically suicidal at the national level for any country not to make these therapies available for everyone who is old enough to need them.

The European: How soon could these therapies be made available?
de Grey: In 2004, I first started making predictions about how quickly we would develop them. Back then, I said it would probably take around 25 years. But it was simply a 50/50 probability. I always acknowledged that there is at least a 10% chance that we won’t get them ready for another hundred years in case we found new problems. But a 50/50 chance is enough to be worth fighting for. But what it really depends on is funding. At the earlier stages of the research, the funding is of course the most difficult to obtain, because people are not yet convinced that the research will eventually succeed. So over the past ten years, during which I would have hoped that we would have gotten to obtain a really decisive dramatic result, we only made about three years of progress. But that’s about the amount of progress that I would have expected to make with the amount of money that we have actually received. So I think I got it about right (laughs).

“The whole point of medicine is tinkering with the way the body works”

The European: Many people and organizations should be interested in investing in something so crucial. So why is there still a lack of financing?
de Grey: There are many reasons for that. One is that the private sector is mostly interested in making quick money, and another is that governments are mainly interested in getting re-elected. What they do therefore depends on what the public wants them to do. That is why it’s so important to get the word out and get people to understand that they should not regard aging as a fact of life but as something that they might be able to avoid. Since those two sources of funding are so difficult, I and some other researchers founded the SENSResearch Foundation as a charity, which is supported by philanthropists through donations. Like this, people who have money don’t need to get anyone else’s permission to spend it. But, of course, we still need to persuade more people that this is the world’s most important problem.

The European: How about the pharmaceutical and medical industry?
de Grey: They also essentially just follow the money. They have to do what the costumer is willing to pay for. At the moment, the general public is focused on having medical care when they are already sick. So companies invest in treatment much more than in prevention. Things will only change when the public begins to appreciate the value of preventative maintenance.

The European: Maybe they don’t appreciate it because they are scared to intervene so drastically in evolution?
de Grey: Why should it be scary? The whole point of medicine is tinkering with the way the body works so as to make it work better. So these therapies should not be any scarier than any other medical treatment. But when we talk about evolution, nobody really pays attention to the fact that humanity has already had massive effects on the way that evolution works. The reason, for example, why we have weaker immune systems now and more allergies is basically because we can. Historically speaking, people with weak immune systems used to have a high chance of dying of infections before they had any kids. And now people with weak immune systems can survive because our medicine is good enough.

The European: Is there a risk of overpopulation? If people don’t make space on this planet for a thousand years it could get quite crowded here.
de Grey: If we look at the recent history of humanity, we see that that is not a problem. Whenever any nation reaches a certain level of female education, emancipation, and prosperity, birth rates go down really rapidly because women just don’t choose to have so many kids on average. They are also having them later, so we can expect them to have them much later when they don’t have menopause any more. But the most important thing of all is that the carrying capacity of the planet, the number of people that we can support without an unacceptable environmental impact, is not a fixed number. That number increases as technology improves. As we make better use of renewable energy and develop nuclear fusion, we will diminish our bad effects on the climate. And that is just one example. These things will happen in a relatively short time frame, whereas the demographic changes that may occur as a result of bringing aging under control will only happen very slowly. We are not going to have any 200-year-old people for at least another 100 years – regardless of what happens.

How to End Aging: Aubrey de Grey at TEDxOxbridge

Jonathon Fulkerson
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Jonathon Fulkerson

Undergraduate at The University of Southern Indiana + More Years Less Tears + Your NeXt Computer
After 15+ years as an IT professional. Jonathon decided to return to school in hopes of one day troubleshooting the most universal problem effecting all. Death, pain, and suffering by aging. As an undergraduate he is currently performing research in Dr. Richard Bennetts lab at the University of Southern Indiana, as well as volunteering for various organizations including the Buck Institute for research on Aging.
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A recent talk by the man who inspired me.  Aubrey de Grey – Remember whethor or not we agree with his ideas on anti-aging research is not the point. At the very least he is the worlds LEADING advocate for anti-aging research. He has spent a great deal of his time and money educating the public on the topic and I am very grateful.

Why You are Wrong About Death and Aging

Jonathon Fulkerson
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Jonathon Fulkerson

Undergraduate at The University of Southern Indiana + More Years Less Tears + Your NeXt Computer
After 15+ years as an IT professional. Jonathon decided to return to school in hopes of one day troubleshooting the most universal problem effecting all. Death, pain, and suffering by aging. As an undergraduate he is currently performing research in Dr. Richard Bennetts lab at the University of Southern Indiana, as well as volunteering for various organizations including the Buck Institute for research on Aging.
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Courtesy of ieet.org – LudVan70 – Posted: Jun 25, 2014

BBC HARDtalk speaks to IEET Fellow Dr. Aubrey de Grey who believes it is a proposition that 21st century biotechnology will soon be able to deliver indefinite lifespan.

Dr. Aubrey de Grey is a biomedical gerontologist, a Fellow of the IEET, and the Chief Science Officer of the SENS Foundation. The editor of Rejuvenation Research, the world’s only peer-reviewed journal focused on intervention in aging, he is an advocate of research seeking answers to how molecular and cellular metabolic damage brings about aging and ways humans can intervene to repair and/or obviate that damage.

 

The central goal of Aubrey de Grey’s work is the expedition of developing a true cure for human aging. In his view, the main obstacle to developing such technology is the position of biogerontology at the boundary between basic science and medicine. He believes that the fundamental knowledge necessary to develop truly effective anti-aging medicine mostly exists, but the goal-directed frame of mind that is best suited to turning research findings into tools is very different from the curiosity-driven ethos that generated those findings in the first place.

As a scientist with a training in an engineering discipline, specifically that of computer science, Dr. De Grey believes himself to be well placed to bridge this gap. He attempt to do so in three main ways: by doing basic biogerontology research, identifying and promoting specific technological approaches to the reversal (not merely the prevention) of various aspects of aging, and by arguing in a wide range of forums, extending beyond biologists, for the adoption of a more proactive approach to extending the healthy human lifespan sooner rather than later.

 

Fast Forward 3 Years!

Jonathon Fulkerson
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Jonathon Fulkerson

Undergraduate at The University of Southern Indiana + More Years Less Tears + Your NeXt Computer
After 15+ years as an IT professional. Jonathon decided to return to school in hopes of one day troubleshooting the most universal problem effecting all. Death, pain, and suffering by aging. As an undergraduate he is currently performing research in Dr. Richard Bennetts lab at the University of Southern Indiana, as well as volunteering for various organizations including the Buck Institute for research on Aging.
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Fast forward 3 years and I am at my second university (advancement). I am doing very well (fingers crossed) in the Biology department. My goals are clearly set, and I believe I have beginning to be “known” for what I am wanting to accomplish. (lie to me)

Looking back, I believe this is the video the first got me thinking about regenerative medicine and the possibility of making that research my life. I still not have not formed a personal opinion on Dr. de Grey, or his work. (I have not met him mind you) but at the very least he has been very inspiring (among others).

Here it is for your viewing pleasure. 🙂

jonathon