Category Archives: Supplements

Spermidine found to lengthen lifespan in mice and to promote cardiovascular health

Jonathon Fulkerson
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Jonathon Fulkerson

Undergraduate at The University of Southern Indiana + More Years Less Tears + Your NeXt Computer
After 15+ years as an IT professional. Jonathon decided to return to school in hopes of one day troubleshooting the most universal problem effecting all. Death, pain, and suffering by aging. As an undergraduate he is currently performing research in Dr. Richard Bennetts lab at the University of Southern Indiana, as well as volunteering for various organizations including the Buck Institute for research on Aging.
Jonathon Fulkerson
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Original Article Here Via Medical Xpress

(Medical Xpress)—A large team of researchers with members from several Europeans countries and the U.S. has found that mice fed a compound called spermidine lived longer than ordinary mice and also had better cardiovascular heath. In their paper published in the journal Nature Medicine, the researchers describe experiments they carried out with the compound and mice, what they found and why they believe the compound might provide benefits for humans.

Prior research has found that ingestion of spermidine—which was first discovered in semen samples, hence its name—led to longer lifespans in simple organisms such as fruit flies, yeast and roundworms. In this new study, the researchers sought to find out if the same would prove true for more complex creatures.

The researchers chose mice as their target, feeding some groups water with spermidine mixed in, while other groups received plain water. After observing the rodents over the course of their lifespans, the researchers discovered that those who had been given spermidine lived longer than those who had not—even if the supplement was not given to them until middle age. Closer examination of the rodents revealed that those given the supplement also had better heart function and lower . They also found that rats fed a high-salt diet, which causes , had lower pressure readings when given spermidine.

Prior research had also suggested that the means by which spermidine extended lifespan was by inducing autophagy in heart cells, which is where cells naturally disable parts of themselves that are dysfunctional or no longer necessary. To find out if this might be the case for rodents, the researchers conducted the same experiments using that had a genetic defect that prevented autophagy from taking place and found that feeding them spermidine did not cause them to live longer or to have improved cardiovascular health, suggesting that autophagy may, indeed, be involved in the process.

The acknowledge that there is thus far little evidence that suggests humans might receive the same benefits from consuming the compound, but note that they did conduct a survey of approximately 800 people regarding their diets and found that those that reported eating foods that contained a fair amount of the compound (mushrooms, whole grains, aged cheese, etc.) had fewer cardiovascular disease symptoms including . They suggest a much larger study should be undertaken before any real conclusions can be made.

Explore further: Healthy ageing—longer healthspan with spermidine

More information: Tobias Eisenberg et al. Cardioprotection and lifespan extension by the natural polyamine spermidine, Nature Medicine (2016). DOI: 10.1038/nm.4222

Abstract
Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. Spermidine feeding enhanced cardiac autophagy, mitophagy and mitochondrial respiration, and it also improved the mechano-elastical properties of cardiomyocytes in vivo, coinciding with increased titin phosphorylation and suppressed subclinical inflammation. Spermidine feeding failed to provide cardioprotection in mice that lack the autophagy-related protein Atg5 in cardiomyocytes. In Dahl salt-sensitive rats that were fed a high-salt diet, a model for hypertension-induced congestive heart failure, spermidine feeding reduced systemic blood pressure, increased titin phosphorylation and prevented cardiac hypertrophy and a decline in diastolic function, thus delaying the progression to heart failure. In humans, high levels of dietary spermidine, as assessed from food questionnaires, correlated with reduced blood pressure and a lower incidence of cardiovascular disease. Our results suggest a new and feasible strategy for protection against cardiovascular disease.

This could be the beginning of More Years and Less Tears – Basis by Elysium Health

Jonathon Fulkerson
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Jonathon Fulkerson

Undergraduate at The University of Southern Indiana + More Years Less Tears + Your NeXt Computer
After 15+ years as an IT professional. Jonathon decided to return to school in hopes of one day troubleshooting the most universal problem effecting all. Death, pain, and suffering by aging. As an undergraduate he is currently performing research in Dr. Richard Bennetts lab at the University of Southern Indiana, as well as volunteering for various organizations including the Buck Institute for research on Aging.
Jonathon Fulkerson
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Time will prove the validity of this supplement, but time is ticking. I submit to you the first major commercial anti-aging supplement to be introduced by anti-aging research scientist since the inception of this blog.

Link to the product here.

BASIS BY ELYSIUM

Science has enabled us to focus on the cellular level to achieve optimal health, beyond what can be accomplished with diet and exercise. Basis is designed to optimize NAD+ levels and sirtuin function in our cells to support our most critical metabolic processes like cellular detoxification, DNA repair and energy production.

Background

Basis exemplifies Elysium’s focus on providing direct access
to scientific breakthroughs in health.

The encapsulation of 35 years of research in a bottle.

For decades, scientists have been searching for answers to what internal mechanisms lead to ongoing health as well as health decline. This led to the discovery of a critical coenzyme called NAD+, which controls cellular communication, and sirtuin proteins, which play a key role in our long-term health. Sirtuin proteins require NAD+ to function, and our NAD+ levels naturally decline over time, leading to a decline in cellular health. With a focus on NAD+ and sirtuins, we can help to sustain their function over time and support the health of the building blocks of our body — our cells. This is the purpose of Basis.

Formulation

Basis contains two novel compounds that support
the production of NAD+ and the activation of sirtuins.

“NAD is one of the most compelling bits of chemistry related to aging. Its presence in the body is directly correlated with the passage of time.”

FAST COMPANY, 2015

  • Nicotinamide RibosideNR
  • PterostilbenePT

Nicotinamide Riboside Pterostilbene

The most direct precursor to NAD+. It is the most readily usable and effective building block for creating more NAD+ inside the cell. NAD+ plays a crucial role in regulating core metabolic functions including cell function, DNA repair and energy production. NAD+ supplies decline naturally with age, thus reducing a cell’s ability to function optimally and potentially impacting baseline health.

Specifications

Learn more about Basis, designed for long-term use
in adults from our 20s onward.

Instructions Take two capsules every morning with or without food. Each jar contains a 30-day supply.
Lead Scientist Dr. Lenny Guarente, Elysium Co-Founder, Leads Science of Aging Lab at MIT.
Purity Assessment Basis undergoes rigorous third party testing to confirm its content accurately reflects the ingredients listed on our label. Two capsules of Basis in our current lot contain 109% of promised quantity of NR, 112% of promised quantity of Pterostilbene.
Analysis Through our established laboratory model, Basis meets standard measures of safety and tolerability.
Both primary ingredients in Basis are GRAS (generally recognized as safe) under intended conditions of use by qualified experts.
Feedback Subtle changes in overall feeling of well-being, sleep quality, energy consistency, cognitive function, and skin health are often reported within 4-16 weeks of starting. Note that cellular health may not always manifest results at the surface.
Dietary Basis is vegetarian, vegan, gluten-free, nut-free, and contains no artificial colors or flavors.
See ingredient information here.
Production Basis is created in the United States in adherence with the FDA’s Good Manufacturing Practices.

Research

Review the scientific research that led to Basis
and how it can impact our cellular health.

  • Cellular DetoxificationCD
  • DNA RepairDR
  • Circadian Rhythm & SleepCRS
  • Protein FoldingPF
  • Mitochondrial Health & EnergyMHE
  • CognitionC
  • All Research Papers

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